1. The expression given is 1+*+5+21+52+65+1. 2. We notice there is a syntax error due to the operator combination '+*+'. 3. Normally, in algebra, an operator like '+' should be followed by a number or variable, not a '*+'. 4. Assuming the intended expression is 1+5+21+52+65+1 (removing '*+'), we proceed. 5. Sum all numbers: 1+5=6; 6+21=27; 27+52=79; 79+65=144; 144+1=145. 6. Therefore, the simplified and corrected sum is $145$.